Chemical Biology of opioid receptors

Research in the Majumdar laboratory is aimed at attaining functional selectivity of opioid agonist action from its on target adverse effects while integrating chemical synthesis with biochemical, genetic and pharmacological approaches. Work from the laboratory has led to probes which display G-protein biased signaling, chemistry and pharmacology of kratom, ligands selective for splice variants of mu opioid receptor agonists and aided the structural of mu and kappa opioid receptor probes.